Beige mouse model for Mycobacterium avium complex disease
نویسندگان
چکیده
منابع مشابه
Liposomal amikacin: improved treatment of Mycobacterium avium complex infection in the beige mouse model.
Disseminated Mycobacterium avium complex (MAC) infection has reached epidemic proportions and is a major cause of morbidity and mortality in AIDS patients. We have developed a liposomal preparation of amikacin, VS107, which incorporates the drug in 54-65 nm diameter unilameller phospholipid vesicles and is stable at 4 degrees C for more than 4 months. VS107 exhibits superior microbiological and...
متن کاملPharmacokinetics, toxicity, and efficacy of liposomal capreomycin in disseminated Mycobacterium avium beige mouse model.
Capreomycin was incorporated into multilamellar vesicles of pure dipalmitoylphosphatidylcholine. The pharmacokinetics and nephrotoxicity of capreomycin in the free and liposomal forms were studied in normal mice. The efficacies of the two forms were evaluated by using the Mycobacterium avium complex beige mouse model. Approximately 10(7) viable M. avium cells were injected intravenously. Seven ...
متن کاملConsolidations in Nodular Bronchiectatic Mycobacterium Avium Complex Lung Disease: Mycobacterium Avium Complex or Other Infection?
PURPOSE The objective of this study is to define the clinical implications of consolidations in nodular bronchiectatic type Mycobacterium avium complex (NBMAC) infection. MATERIALS AND METHODS A total of 69 patients (M : F = 17 : 52; mean age, 64 years; age range, 41-85 years) with MAC isolated in the sputum culture and nodular bronchiectasis on the initial and follow-up CT scans were include...
متن کاملComparative activities of amikacin against Mycobacterium avium complex in nude and beige mice.
After 4 weeks of treatment, clarithromycin (CLAR) and amikacin showed similar antimicrobial activities against the Mycobacterium avium complex in mice. There was a difference, however, in the effectiveness of the drugs in different types of mice: both drugs displayed bactericidal effects in beige mice but only bacteriostatic effects in nude mice. Because the effectiveness of CLAR is less in nud...
متن کاملMycobacterium Avium Complex
These two species are difficult to differentiate and therefore they are also referred to collectively as Mycobacterium avium-intracellulare (MAI) . Although it might more logically be termed the Mycobacterium avium-intracellulare complex such nomenclature has not been adopted. They are both opportunistic pathogens that affect the immunocompromised, particularly HIV-positive individuals. They ca...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1995
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.39.8.1647